Reacción #302890

Ecuación de reacción

2,3-dichlorobenzylamine

2-chloroethylisothiocyanate

→

title compound

Rendimiento 163.2%

((2,3-dichlorophenyl)methyl)-1,3-thiazolin-2-ylamine hydrochloride

Rendimiento 163.2%

Disolventes

1,4-dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas placed in a sealed reaction vial
2. 2
   Temperaturato cool
3. 3
   Otroa solid precipitate that had formed
4. 4
   Filtraciónwas collected by filtration
5. 5
   LavadoThe solid was rinsed with diethyl ether
6. 6
   Otrowas dried under reduced pressure

Procedimiento

A mixture of 0.5 gram (0.0028 mole) of 2,3-dichlorobenzylamine and 0.27 gram (0.0081 mole) of 2-chloroethylisothiocyanate in 10 mL of 1,4-dioxane was placed in a sealed reaction vial. The reaction mixture was heated to 80° C. where it stirred for about 18 hours. The reaction mixture was allowed to cool and a solid precipitate that had formed was collected by filtration. The solid was rinsed with diethyl ether and was dried under reduced pressure to yield 0.68 gram of the title compound. The NMR spectrum was consistent with the proposed structure.

Fuente