Reacción #302862

ord-e4a4856015b747faa4a7eb10e50a9f34

Ecuación de reacción

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine
→
CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.NCCc1c[nH]cn1.O=C(O)CCC(=O)O
histamine dipalmitoylglycerol succinate

Reactantes

CCCCCCCCCCCCCCCC(=O)C(O)C(O)C(O)C(=O)CCCCCCCCCCCCCCC.O=C(O)CCC(=O)O
dipalmitoylglycerol succinate
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
NCCc1c[nH]cn1
histamine

Reactivos

Ninguno

Disolventes

CN(C)C=O
DMF
CN(C)C=O
DMF

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    workup.STIRRINGThe mixture is stirred overnight
  2. 2
    Concentraciónconcentrated thoroughly in vacuum
  3. 3
    OtroThe residue is purified

Procedimiento

1.7 g of dipalmitoylglycerol succinate is dissolved in 20 ml of DMF at room temperature. The solution is added with 400 mg of carbonyldiimidazole dissolved in 20 ml of DMF. The mixture is allowed to stir for 1 hour and subsequently added with 300 mg of histamine. The mixture is stirred overnight and concentrated thoroughly in vacuum. The residue is purified using column chromatography on silica gel 60, with chloroform/methanol 10:1 being used as eluant.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08192753B2uspto-grants-2012_06