Reacción #302847

Ecuación de reacción

compound 3

1-(5-bromo-2-hydroxyphenyl)-3-(4-nitrophenyl)propan-1,3-dione

sulfuric acid

→

compound 4

6-bromo-4′-nitroflavone

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturato reflux for 1 hour
3. 3
   Otrowas returned to room temperature
4. 4
   workup.ADDITIONice pieces were then added to the reaction solution
5. 5
   FiltraciónThe precipitated crystal was collected by filtration

Procedimiento

A mixed solution consisting of compound 3 (2.00 g, 5.49 mmol), concentrated sulfuric acid (0.5 ml), and acetic acid (40 ml) was heated to reflux for 1 hour. The temperature of the resultant was returned to room temperature, and ice pieces were then added to the reaction solution. The precipitated crystal was collected by filtration, so as to obtain a product of interest, 6-bromo-4′-nitroflavone (compound 4). Yield: 1.79 g (yield constant: 94.2%) MS m/z 347 (MH+).

Fuente