Reacción #2950

Ecuación de reacción

N,N-diisopropyl-3-oxobutyramide

NaOH

phenyldiazonium chloride

→

title compound

Rendimiento 68.2%

N,N-Diisopropyl-2-phenylhydrazono-3-oxobutyramide

Rendimiento 68.2%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroas described in preparation 8
2. 2
   OtroThe crude reaction mixture
3. 3
   Otrowas purified by chromatography on silica gel (hexane/Et2O 95:5)

Procedimiento

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

Fuente