Reacción #2947

ord-eb592b1203c74e969732293b7513ee02

Ecuación de reacción

C=C1CC(=O)O1.CC(C)=O
diketene acetone
CNC
dimethylamine
→
CC(=O)CC(=O)N(C)C
title compound
CC(=O)CC(=O)N(C)C
N,N-Dimethyl-3-oxobutyramide

Reactantes

C=C1CC(=O)O1.CC(C)=O
diketene acetone
CNC
dimethylamine

Reactivos

Ninguno

Disolventes

Cc1ccccc1
toluene

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe solvent was removed in vacuo
  2. 2
    Otrothe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

Procedimiento

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05731322uspto-grants-1998_03