Reacción #2945

Ecuación de reacción

diketene acetone

pyrrolidine

→

title compound

Rendimiento 97.9%

1-(3-Oxobutyryl)pyrrolidine

Rendimiento 97.9%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroas described in preparation 7
2. 2
   OtroThe solvent was removed in vacuo
3. 3
   Otrothe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

Procedimiento

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

Fuente