Reacción #2892

Ecuación de reacción

sodium hydroxide

3-Chloropentane-2,4-dione

propionamide

propionic acid

→

5-Acetyl-2-ethyl-4-methyloxazole

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with dichloromethane
2. 2
   LavadoThe combined extracts were washed with brine
3. 3
   Otrodried
4. 4
   Otrothe solvent removed
5. 5
   Otroto leave a brown oil which
6. 6
   workup.DISTILLATIONwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

Procedimiento

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

Fuente