Reacción #2876

Ecuación de reacción

N-bromosuccinimide

5-bromo-2-fluoro-benzyl alcohol

triphenyl phosphine

→

title compound

Rendimiento 96.7%

5-Bromo-2-fluoro-benzyl bromide

Rendimiento 96.7%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe ice bath is removed
2. 2
   OtroThe crude product is purified by column chromatography
3. 3
   Lavadoeluting with 5% EtOAc/hexanes

Procedimiento

To a solution of 5-bromo-2-fluoro-benzyl alcohol (3.10 g, 15.1 mmol) in 30 mL of THF at 10° C. is added triphenyl phosphine (4.10 g, 15.6 mmol) followed by N-bromosuccinimide (2.67 g, 15.0 mmol). The ice bath is removed and the resulting solution is stirred for 20 min at room temperature. The crude product is purified by column chromatography eluting with 5% EtOAc/hexanes to give the title compound (3.90 g, 14.5 mmol).

Fuente