Reacción #2693

Ecuación de reacción

n-butyllithium

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole

water

4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)

→

Bis-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxol-4-yl)-mono-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole-4-yl)methanol

Disolventes

ether

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONfilled
2. 2
   Otroreaction vessel
3. 3
   Temperaturathe mixture was cooled to 0° C.
4. 4
   workup.STIRRINGThe reaction was stirred at ambient temperature overnight
5. 5
   OtroThe organic layer was separated
6. 6
   Lavadothe aqueous phase was washed once more with ether
7. 7
   SecadoThe organic phase was dried (Na2SO4)
8. 8
   Otroevaporated
9. 9
   Otroto give a semisolid residue
10. 10
    OtroThe product was recrystallized from acetonitrile

Procedimiento

2,2,6,6-Tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dioxole (5.15 g, 23.2 mmol) was dissolved in dry ether (40.0 mL) in a dried, argon filled reaction vessel. The solution was cooled to 0° C. and n-butyllithium (9.29 mL, 2.5M in hexane) was added. After stirring for 15 min at ambient temperature, the mixture was cooled to 0° C. and 4-methoxycarbonyl-(2,2,6,6-tetramethylbenzo[1,2-d:4,5-d']-bis(1,3)dithiole)(4.0 g, 11.6 mmol) was added portionwise. The reaction was stirred at ambient temperature overnight. The voluminous precipitate was dissolved by addition of water (70 mL) and ether (50 mL). The organic layer was separated and the aqueous phase was washed once more with ether. The organic phase was dried (Na2SO4) and evaporated to give a semisolid residue. The product was recrystallized from acetonitrile. Yield of pure product was 5.26 g (60%).

Fuente