Reacción #2619

Ecuación de reacción

4-[(S)-2-Aminopropionyl]aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide

oxalic acid

→

title compound

Rendimiento 85.1%

4-[(S)-2-Aminopropionyl]aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide dioxalate

Rendimiento 85.1%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otromethanol was removed by evaporation
2. 2
   Lavadothe resulting amorphous residue was washed with acetone (5 ml)
3. 3
   Filtracióncollected by filtration

Procedimiento

4-[(S)-2-Aminopropionyl]aminomethyl-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(2-methoxyphenyl)benzamide (84.7 mg, 0.155 mmol) was dissolved in methanol (5 ml) and mixed with oxalic acid (28 mg, 0.311 mmol). After 5 minutes of stirring at room temperature, methanol was removed by evaporation, and the resulting amorphous residue was washed with acetone (5 ml) and collected by filtration to obtain 84 mg (85.1%) of the title compound in a colorless amorphous powder form.

Fuente