Reacción #2609

Ecuación de reacción

ammonium chloride

sodium hydride

4-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide

methyl iodide

→

title compound

Rendimiento 80.4%

4-(N-Methylacetylamino)-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide

Rendimiento 80.4%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat room temperature
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe resulting organic layer was washed with water and saturated brine
4. 4
   Secadodried on anhydrous sodium sulfate
5. 5
   OtroThereafter, the solvent was removed by evaporation
6. 6
   Otrothe resulting residue was recrystallized from methanol-ether

Procedimiento

4-Acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(4-methoxyphenyl)benzamide (155.0 mg, 0.30 mmol) was dissolved in THF (3.0 ml) to which were subsequently added 60% sodium hydride {28.0 mg, 0.70 mmol) and methyl iodide (0.060 ml, 1.00 mmol) at room temperature, followed by 2 hours of stirring. The reaction solution was mixed with saturated ammonium chloride aqueous solution and extracted with ethyl acetate. The resulting organic layer was washed with water and saturated brine, and dried on anhydrous sodium sulfate. Thereafter, the solvent was removed by evaporation, and the resulting residue was recrystallized from methanol-ether to obtain 128.0 mg (80.4%) of the title compound in a colorless powder form.

Fuente