Reacción #2560

Ecuación de reacción

N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide

triethylamine

→

title compound

Rendimiento 65.6%

N-Formylmethyl-3-methoxy-N-(2-methoxyphenyl)benzamide

Rendimiento 65.6%

Disolventes

DMSO

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroat room temperature
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   Lavadowashed with water and saturated brine
4. 4
   SecadoThe resulting organic layer was dried on anhydrous magnesium sulfate
5. 5
   Otrothe solvent was removed by evaporation

Procedimiento

In an atmosphere of argon, N-(2-hydroxyethyl)-3-methoxy-N-(2-methoxyphenyl)benzamide (339 mg, 1.12 mmol) was dissolved in DMSO (4 ml) to which were subsequently added dropwise triethylamine (0.724 ml, 5.20 mmol) and a DMSO solution (8 ml) of a sulfur trioxide-pyridine complex (844 mg, 5.20 mmol) at room temperature. After 20 minutes of stirring at the same temperature, this was mixed with ice water (40 ml) and extracted with ethyl acetate, and then washed with water and saturated brine. The resulting organic layer was dried on anhydrous magnesium sulfate, and the solvent was removed by evaporation to obtain 220 mg (65.6%) of the title compound the form of light yellow solid.

Fuente