Reacción #2556

Ecuación de reacción

4-(4-Fluorobenzoyl)piperidine

bromoacetoaldehyde diethylacetal

triethylamine

→

title compound

Rendimiento 25.0%

1-(2,2-Diethoxyethyl)-4-(4-fluorobenzoyl)piperidine

Rendimiento 25.0%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter 12 hours of heating
2. 2
   Temperaturaunder reflux
3. 3
   Otrothe solvent was removed by evaporation
4. 4
   Otrothe resulting residue was purified

Procedimiento

4-(4-Fluorobenzoyl)piperidine (207 mg, 1.0 mmol) was dissolved in methylene chloride (5 ml) to which were subsequently added bromoacetoaldehyde diethylacetal (305 mg, 1.5 mmol) and triethylamine (0.5 ml). After 12 hours of heating under reflux, the solvent was removed by evaporation, and the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 81 mg (25.0%) of the title compound in the form of orange oil.

Fuente