Reacción #2555

Ecuación de reacción

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride

sodium carbonate

→

title compound

Rendimiento 92.3%

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine

Rendimiento 92.3%

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaWith cooling in an ice bath
2. 2
   ExtracciónThe reaction solution was extracted with ether
3. 3
   Lavadowashed with saturated brine
4. 4
   Secadothe resulting organic layer was dried on anhydrous sodium carbonate
5. 5
   FiltraciónThereafter, the organic layer was filtered through silica gel (5 g)
6. 6
   Otrothe solvent was removed by evaporation
7. 7
   Otrothe resulting residue was purified

Procedimiento

1-(2-Chloroethyl)-4-(4-fluorobenzoyl)piperidine hydrochloride (800 mg, 2.61 mmol) was suspended in ether (20 ml). With cooling in an ice bath, saturated sodium carbonate aqueous solution (5 ml) was added dropwise to the suspension. The reaction solution was extracted with ether and washed with saturated brine, and the resulting organic layer was dried on anhydrous sodium carbonate. Thereafter, the organic layer was filtered through silica gel (5 g), the solvent was removed by evaporation and then the resulting residue was purified by subjecting it to a silica gel column chromatography (ether) to obtain 650 mg (92.3%) of the title compound in the form of light yellow solid.

Fuente