Reacción #2551

Ecuación de reacción

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

Rendimiento 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

Rendimiento 100.0%

Disolventes

dioxane

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   SecadoAfter drying on anhydrous sodium carbonate
4. 4
   Otrothe solvent was removed by evaporation

Procedimiento

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

Fuente