Reacción #2493763

Ecuación de reacción

29

2-Cyano-N-(1-(4-(2-(diethylamino)ethoxy)phenyl)butyl)acetamide

1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)butan-1-amine

1-(4-(2-(Pyrrolidin-1-yl)ethoxy)phenyl)butan-1-amine

→

31

Rendimiento 60.0%

2-Cyano-N-(1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)butyl)acetamide

Rendimiento 60.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe title compound was prepared
2. 2
   OtroThis produced crude product which
3. 3
   Otrowas purified by flash silica gel column chromatography
4. 4
   Lavadoeluting with 5:95 methanol/dichloromethane

Procedimiento

The title compound was prepared by using a similar procedure as described for the preparation of 29 except that 1-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)butan-1-amine (27) was used instead of 1-(4-(2-(diethylamino)ethoxy)phenyl)butan-1-amine (25). This produced crude product which was purified by flash silica gel column chromatography, eluting with 5:95 methanol/dichloromethane, to give 31 (140 mg, 60%) as a thick yellow oil: MS (ES+) m/z 330.2 (M+H)+.

Fuente