Reacción #2487449

Ecuación de reacción

2-Amino-4-trifluoromethylbenzoic acid

urea

→

7-Trifluoromethyl-1H-quinazoline-2,4-dione

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturato cool to 100° C.
2. 2
   Temperaturato cool to room temperature
3. 3
   Otrothe solid was isolated by vacuum filtration
4. 4
   Lavadowashing with water (500 mL)
5. 5
   OtroThe solid was then dried under vacuum (10 mbar, 50° C.)
6. 6
   Otro2.1 min, 230 (M+)

Procedimiento

2-Amino-4-trifluoromethylbenzoic acid (25.0 g, 122 mmol) and urea (75.0 g, 1.2 mol) were combined and heated at 200° C. while stirring. After 1 h, the reaction mixture was allowed to cool to 100° C. and water (100 mL) was added. The reaction mixture was then allowed to cool to room temperature and the solid was isolated by vacuum filtration washing with water (500 mL). The solid was then dried under vacuum (10 mbar, 50° C.). Yield=24 g, 86%; LC-MS: 2.1 min, 230 (M+); 1H NMR (DMSO-d6) δ 7.44 (s, 1 H) 7.47 (d, 1 H), 8.07 (d, 1 H), 11.43 (br s, 1 H), 11.56 (br s, 1 H).

Fuente