Reacción #2487446

Ecuación de reacción

2-amino-4-(trifluoromethyl)benzamide

4-chlorobenzaldehyde

→

2-(4-Chlorophenyl)-7-trifluoromethyl-3H-quinazolin-4-one

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was then heated
2. 2
   Temperaturaat reflux for 24 h
3. 3
   Otrothe precipitate was isolated by vacuum filtration
4. 4
   Lavadowashing with water (3×500 mL)
5. 5
   Otrodried under vacuum (10 mbar, 50° C.)
6. 6
   Otro3.7 min, 325 (M+)

Procedimiento

To a stirred suspension of 2-amino-4-(trifluoromethyl)benzamide (33.6 g, 0.16 mol) in water (750 mL) was added dropwise 4-chlorobenzaldehyde. Iron trichloride hexahydrate (133 g) was then added in portions. The reaction mixture was then heated at reflux for 24 h. After allowing the suspension to cool to room temperature, the precipitate was isolated by vacuum filtration washing with water (3×500 mL) and dried under vacuum (10 mbar, 50° C.). Yield=50 g, 94%; HPLC-mass spectrometry (LC-MS): 3.7 min, 325 (M+).

Fuente