Reacción #2486786

Ecuación de reacción

cyclohexane

4-(4-propylcyclohexyl)cyclohexane

acetone

water

→

3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby heating the solution
2. 2
   Temperaturaunder reflux for 4 hours
3. 3
   Extracciónextracting with ether (50 ml)
4. 4
   Secadodrying the organic layer over anhydrous magnesium sulfate
5. 5
   Concentraciónconcentrating under reduced pressure

Procedimiento

The resulting cyclohexane derivative was dissolved in a mixed solvent of acetone (80 ml) with 2N hydrochloric acid (8 ml) , followed by heating the solution under reflux for 4 hours, cooling the reaction mixture down to room temperature after completion of the stirring, adding water, extracting with ether (50 ml), drying the organic layer over anhydrous magnesium sulfate, and concentrating under reduced pressure to obtain 3-(4-(4-propylcyclohexyl)cyclohexyl)-2E-propenal (3.1 g, 12 mmols). This product was used in the subsequent reaction without any purification.

Fuente