Reacción #2474105

Ecuación de reacción

2-ethyl-4H-3,1-benzoxazin-4-one

4-aminophenol

→

compound

Rendimiento 66.0%

2-ethyl-3-(4-hydroxyphenyl)-4-(3H)-quinazolinone

Rendimiento 66.0%

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter leaving
2. 2
   Temperaturato cool to room temperature
3. 3
   workup.DISTILLATIONdistilled water (94 mL)
4. 4
   workup.ADDITIONwas added
5. 5
   Filtraciónthe solid precipitate was filtered off
6. 6
   OtroThe product was recrystallized (ethanol)

Procedimiento

2-ethyl-4H-3,1-benzoxazin-4-one (6.5 g, 37.1 mmol) and 4-aminophenol (4.05 g, 37.1 mmol) were dissolved in dimethylformamide (18 mL) and stirred at 140° C. for 10 hours. After leaving to cool to room temperature, distilled water (94 mL) was added, and the solid precipitate was filtered off. The product was recrystallized (ethanol) and the target compound (6.52 g, 66%) was obtained as light brown crystals.

Fuente