Reacción #2471752

Ecuación de reacción

4-hydroxy-1-naphtaldehyde

4-(dicyanomethylene)-2,6-dimethyl-4H-pyrane

piperidine

→

desired compound

Rendimiento 48.2%

((E)-2-(2-(4-hydroxynaphthalene-1-yl)vinyl)-6-methyl-4H-pyrane-4-ylidene)malononitrile

Rendimiento 48.2%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe resultant was heated
2. 2
   Temperaturarefluxed under an argon atmosphere for 6 hours
3. 3
   Otrothe solvent was removed under reduced pressure
4. 4
   Otrofollowed by purification by column chromatography (SiO2, CHCl3:MeOH=10:1 (v/v))

Procedimiento

4-hydroxy-1-naphtaldehyde (0.70 g (5.81 mmol)), 4-(dicyanomethylene)-2,6-dimethyl-4H-pyrane (1.0 g (5.81 mmol)), piperidine (0.50 g (5.81 mmol)), and ethanol (50 mL) were added to a 50-mL three-neck flask. The resultant was heated and refluxed under an argon atmosphere for 6 hours and then the solvent was removed under reduced pressure, followed by purification by column chromatography (SiO2, CHCl3:MeOH=10:1 (v/v)). Thus a desired compound was obtained (yield: 48.2%).

Fuente