Reacción #2468007

Ecuación de reacción

benzyl 4-(4-nitro-phenyl)-piperazine-1-carboxylate

→

benzyl 4-(4-amino-phenyl)-piperazine-1-carboxylate

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThen the mixture is filtered
2. 2
   Otroto remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid
3. 3
   workup.ADDITIONare added

Procedimiento

11.28 g benzyl 4-(4-nitro-phenyl)-piperazine-1-carboxylate are dissolved in 500 mL MeOH and combined with 1 g Raney nickel. The mixture is hydrogenated for 18 h at 5 bar H2 pressure. Then the mixture is filtered to remove the catalyst, 70 mL of 1 N aqueous hydrochloric acid are added and the solvent is eliminated in vacuo.

Fuente