Reacción #2468005

ord-e73142bd30874a93aca363f3d2483565

Ecuación de reacción

CC(CN)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1
2-(1-trityl-1H-imidazol-4-yl)-propylamine
C=O
formaldehyde
→
CC1CNCC2N=CNC12
7-methyl-3a.4,5,6,7.7a-hexahydro-1H-imidazo[4,5-c]pyridine

Reactantes

CC(CN)c1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1
2-(1-trityl-1H-imidazol-4-yl)-propylamine
C=O
formaldehyde
—
crude product

Reactivos

Ninguno

Disolventes

Cl
HCl

Condiciones de reacción

Temperatura
95°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    TemperaturaAfter 5 h it is cooled to RT
  2. 2
    Filtraciónsuction filtered
  3. 3
    Otroto remove the precipitate
  4. 4
    Otroformed

Procedimiento

3.2 g 2-(1-trityl-1H-imidazol-4-yl)-propylamine is suspended in aqueous HCl (1 N). After the addition of 2.9 mL formaldehyde the mixture is heated to 95° C. with stirring. After 5 h it is cooled to RT, suction filtered to remove the precipitate formed and the solvent is eliminated in vacuo. This crude product is used in the following reaction step without further purification.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08258129B2uspto-grants-2012_09