Reacción #2468000

Ecuación de reacción

(S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine

sodium acetate

→

(R)-2-(3H-imidazol-4-yl)-1-methyl-ethylamine

Disolventes

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónAfter the catalyst has been filtered off the solvent
2. 2
   Otrothe crude product is used without further purification in the following reaction step

Procedimiento

1.5 g (S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine and 1.87 g sodium acetate are dissolved in 94 mL acetic acid (10%). After the addition of 400 mg palladium/C the suspension is shaken under 3.5 bar H2 pressure at RT for about 60 h. After the catalyst has been filtered off the solvent is eliminated in vacuo and the crude product is used without further purification in the following reaction step.

Fuente