Reacción #2467985

Ecuación de reacción

Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

Rendimiento 65.0%

Methyl 4-aminothiophene-3-carboxylate

Rendimiento 65.0%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe solution was extracted with chloroform
2. 2
   Lavadothe combined chloroform layer was washed with water, brine
3. 3
   Secadodried over sodium sulfate
4. 4
   FiltraciónThe solution was filtered
5. 5
   Otroevaporated the solvent

Procedimiento

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

Fuente