Reacción #2467982

Ecuación de reacción

acrylate

Methyl acrylate

methyl thioglycolate

piperidine

acrylate

piperidine

→

product

Rendimiento 100.0%

Methyl 3-[(methoxycarbonyl)methylthio]propanoate

Rendimiento 100.0%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe chloroform layer was washed with water, brine
2. 2
   Secadodried over Na2SO4
3. 3
   FiltraciónThe solution was filtered
4. 4
   Otroevaporated the solvent

Procedimiento

Methyl acrylate (4.25 g, 49.5 mmol) was added dropwise over 20 min to a stirred solution of methyl thioglycolate (5 g, 47.16 mmol) and piperidine (0.10 mL) at rt. When about half of the acrylate had been introduced, more piperidine (0.10 mL) was added. After completion of the addition of the acrylate, the reaction mixture was stirred for 1 h at rt. The mixture was diluted with 100 mL of chloroform. The chloroform layer was washed with water, brine and dried over Na2SO4. The solution was filtered and evaporated the solvent to give the product as an oil (9 g, 100%).

Fuente