Reacción #2467014

Ecuación de reacción

2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide

diaminomethylenethiourea

→

4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

Rendimiento 42.4%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 10 hours
2. 2
   OtroThe resulting precipitate was collected
3. 3
   workup.DISSOLUTIONdissolved in water (50 ml)
4. 4
   OtroThe separated product was collected
5. 5
   Lavadowashed with water

Procedimiento

A mixture of 2-(acetylaminometyl)-6-bromoacetylpyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

Fuente