Reacción #2460338

ord-42eb0222d0924b0c86fd851cbf3ed77e

Ecuación de reacción

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid
→
CCS(=O)(=O)[O-].Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
Olanzapine Esylate

Reactantes

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CCS(=O)(=O)O
ethane sulfonic acid

Reactivos

Ninguno

Disolventes

CC(C)=O
acetone
CC(C)=O
acetone

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroto form
  2. 2
    Otrothe crystals were isolated by filtration
  3. 3
    Lavadowashed with 50 ml acetone

Procedimiento

To a solution of 5.0 g of olanzapine base in 150 ml acetone was added 1.76 g ethane sulfonic acid in 50 ml acetone at room temperature. Immediately a solid started to form. After stirring for 3 hours, the crystals were isolated by filtration and washed with 50 ml acetone. Yield: 6.59 g (97%).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07459449B2uspto-grants-2008_12