Reacción #2460335

ord-2c52ce0473ba490ba0fc185ddb73e220

Ecuación de reacción

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)CO
glycolic acid
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
→
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1.O=C([O-])CO
Olanzapine Glycolate

Reactantes

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
O=C(O)CO
glycolic acid
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine

Reactivos

Ninguno

Disolventes

CC(C)=O
acetone
CC(C)=O
acetone

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroThe formed crystals were isolated by filtration
  2. 2
    Otrodried overnight at 40° C. in vacuo
  3. 3
    OtroIsolated yield: 84.1 gram (90%)

Procedimiento

To a clear solution of 75 g olanzapine free base in 1500 ml acetone, was added slowly 18.0 g glycolic acid in 100 ml acetone at room temperature. The resulting mixture was stirred at room temperature overnight. The formed crystals were isolated by filtration and dried overnight at 40° C. in vacuo. Isolated yield: 84.1 gram (90%). 1H-NMR confirms the molar ratio olanzapine:acid=1:1.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07459449B2uspto-grants-2008_12