Reacción #2460334

Ecuación de reacción

olanzapine

glycolic acid

→

Olanzapine Glycolate

Disolventes

acetone

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crystals were isolated by filtration
2. 2
   Lavadowashed with 15 ml of acetone and 20 ml of ether
3. 3
   Otrodried overnight at 40° C. in vacuo

Procedimiento

To a solution of 5.0 g of olanzapine in 150 ml of acetone was added 1.22 g of glycolic acid in 25 ml acetone slowly at room temperature. The mixture was stirred overnight at 4° C. The crystals were isolated by filtration, washed with 15 ml of acetone and 20 ml of ether and dried overnight at 40° C. in vacuo. Yield: 5.76 g

Fuente