Reacción #2460284

Ecuación de reacción

4-Bromophenol

potassium carbonate

benzyl bromide

→

4-benzyloxybromobenzene

Disolventes

water

acetone

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was refluxed under nitrogen
2. 2
   TemperaturaAfter 5-6 hours of reflux
3. 3
   Otrothe organic layer was separated
4. 4
   Secadodried over magnesium sulfate
5. 5
   Otroevaporated to dryness
6. 6
   Otroto afford a white fluffy powder

Procedimiento

4-Bromophenol (2 g, 0.0116 mol) in acetone (40 ml) was treated with potassium carbonate (1.91 g, 1.2 equivalents) and benzyl bromide (1.44 ml, 1.05 equivalents). The reaction was refluxed under nitrogen. After 5-6 hours of reflux, the reaction was cooled to room temperature and diluted with an equal volume of ethyl acetate. This was diluted further with water and the organic layer was separated, dried over magnesium sulfate and evaporated to dryness to afford a white fluffy powder. Yield=2.36 g (73%).

Fuente