Reacción #2457908

ord-350356b8451c4b1593617b80e183ce0a

Ecuación de reacción

CC(C)(C)OC(=O)N[C@H]1CC[C@H](Oc2ccc3cnccc3c2Cl)CC1
trans-[4-(5-Chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester
Cl
HCl
→
N[C@H]1CC[C@H](Oc2cc3ccncc3cc2Cl)CC1
title compound
N[C@H]1CC[C@H](Oc2cc3ccncc3cc2Cl)CC1
trans-4-(7-Chloro-isoquinolin-6-yloxy)-cyclohexylamine

Reactantes

CC(C)(C)OC(=O)N[C@H]1CC[C@H](Oc2ccc3cnccc3c2Cl)CC1
trans-[4-(5-Chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester
Cl
HCl

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otrothe solvent was removed i
  2. 2
    Otroand the residue was purified by preparative HPLC

Procedimiento

18 mg (0.05 mmol) trans-[4-(5-Chloro-isoquinolin-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester (10) were stirred in 2 M HCl at room temperature. After 2 days, the solvent was removed i. vac. and the residue was purified by preparative HPLC. 8 mg of the title compound could be obtained as trifluoro acetate. Rt=0.69 min (Method #1). Detected mass: 277.2/279.2 (M+H+).

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08710228B2uspto-grants-2014_04