Reacción #2457472

Ecuación de reacción

2-methyl-propane-2-sulfinic acid [4-(7-chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-amide

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title compound 71

Rendimiento 3.0%

6-(4-Amino-4-phenyl-cyclohexyloxy)-7-chloro-2H-isoquinolin-1-one

Rendimiento 3.0%

Disolventes

2-propanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated
2. 2
   Otropurified by preparative HPLC
3. 3
   workup.DISSOLUTIONThe respective residue was redissolved in water
4. 4
   Otroto give the hydrochloride

Procedimiento

4.5 mg of the title compound 71 were prepared as diastereomeric mixture from 190 mg (0.40 mmol) of 2-methyl-propane-2-sulfinic acid [4-(7-chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-1-phenyl-cyclohexyl]-amide (crude, 70) by stirring in a mixture of 2-propanol/0.5N aqueous HCl (2:1) until complete conversion. The reaction mixture was concentrated and purified by preparative HPLC. The resultant trifluoroacetate was taken up in 1N HCl twice and lyophilized. The respective residue was redissolved in water and lyophilized again to give the hydrochloride. Rt=0.91 min, 0.94 min (Method C). Detected mass: 369.2 (M+H+).

Fuente