Reacción #2457455
ord-3ac159207fa3437f86df0455b43bcdf4
Ecuación de reacción
2-(4-methoxy-benzyl)-6-fluoro-2H-isoquinolin-1-one
6-Fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
4-allyl-4-amino-cyclohexanol
4-Allyl-4-amino-cyclohexanol
6-(4-allyl-4-amino-cyclohexyloxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
6-(4-Allyl-4-amino-cyclohexyl oxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
→
Reactantes
2-(4-methoxy-benzyl)-6-fluoro-2H-isoquinolin-1-one
6-Fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
4-allyl-4-amino-cyclohexanol
4-Allyl-4-amino-cyclohexanol
6-(4-allyl-4-amino-cyclohexyloxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
6-(4-Allyl-4-amino-cyclohexyl oxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Tratamiento posterior
- 1OtroRt=1.07 min, 1.10 min (Method C)
Procedimiento
422 mg of 6-(4-allyl-4-amino-cyclohexyloxy)-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (18) were synthesized as diastereomeric mixture starting from 641 mg (2.26 mmol) of 2-(4-methoxy-benzyl)-6-fluoro-2H-isoquinolin-1-one (9) and 370 mg (2.38 mmol) of 4-allyl-4-amino-cyclohexanol (16), following the protocol described for 6-(4-allyl-4-amino-cyclohexyloxy)-7-chloro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one (17). Rt=1.07 min, 1.10 min (Method C). Detected mass: 419.2 (M+H+).