Reacción #2450368

Ecuación de reacción

tricyclohexylphosphine

3,5-Dichlorobenzotrifluoride

cyclopropylboronic acid

K3PO4

→

1-chloro-3-cyclopropyl-5-trifluoromethyl-benzene

Rendimiento 87.1%

Condiciones de reacción

Procedimiento

3,5-Dichlorobenzotrifluoride (1.10 g, 5.1 mmol) and cyclopropylboronic acid (440 mg, 5.1 mmol) were reacted using K3PO4 (3.8 g, 17.9 mmol), tricyclohexylphosphine (145 mg, 0.51 mmol), Pd(OAc)2 (60 mg, 0.27 mmol) as described in example 100 to give 1-chloro-3-cyclopropyl-5-trifluoromethyl-benzene (980 mg, 87%) after purification by flash chromatography on silica gel.

Fuente