Reacción #2450014

Ecuación de reacción

diethylether

3-bromophenol

potassium carbonate

→

1-bromo-3-cyclopropoxybenzene

Disolventes

water

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe organic layer was separated
2. 2
   Lavadowashed with water, brine
3. 3
   Secadodried over Na2SO4
4. 4
   Filtraciónfiltered
5. 5
   Otroevaporated
6. 6
   OtroAn oil was obtained
7. 7
   OtroThis intermediate was used for the next reaction

Procedimiento

A mixture of 3-bromophenol (2.4 g, 13.9 mmol), bomocyclopropane (6.66 ml, 83 mmol) and potassium carbonate (9.6 g, 69.5 mmol) in DMF (16 ml) was heated at 180° C. in a microwave oven for 8 hours. The reaction mixture was diluted with a mixture of diethylether and water. The organic layer was separated, washed with water, brine, dried over Na2SO4, filtered and evaporated. An oil was obtained, 2.87 g, with a purity of 81%. This intermediate was used for the next reaction.

Fuente