Reacción #2439975

Ecuación de reacción

HCl

Thiophene-2-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

ethyl formate

sodium ethoxide

→

Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Rendimiento 75.4%

Disolventes

ethanol

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroproducing a black oil
2. 2
   TemperaturaSubsequently, the reaction mixture was cooled to room temperature
3. 3
   FiltraciónThe suspension was filtered

Procedimiento

Thiophene-2-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (0.857 g, 2.36 mmol) and ethyl formate (0.567 mL, 7.09 mmol) were dissolved in anhydrous ethanol (4.73 mL). The resulting solution was treated in dropwise fashion with a 21 wt % solution of sodium ethoxide in ethanol (4.4 mL, 11.83 mmol). This reaction mixture was heated at 78° C. for 1 h, producing a black oil. Subsequently, the reaction mixture was cooled to room temperature, and then the reaction pH was adjusted to pH 1 with dropwise addition of 1M HCl(aq) causing the formation of a pale orange precipitate. The suspension was filtered yielding an orange solid as the pure Thiophene-2-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (0.695 g, 1.78 mmol, 75%).

Fuente