Reacción #2439972

Ecuación de reacción

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

5-amino-2-methylphenol

→

title compound

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (4-{3-[(3-hydroxy-4-methyl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-6-carbonyl}-phenyl)-amide

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA small screw cap test tube
2. 2
   TemperaturaSubsequently, the reaction mixture was cooled to room temperature
3. 3
   OtroThe solid precipitate that formed

Procedimiento

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (as prepared in Example 15, 100 mg, 0.240 mmol) and THF (2 mL). To the resulting solution was added 5-amino-2-methylphenol (32.5 mg, 0.1082 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 44% (55 mg, 44 mmol) of the title compound.

Fuente