Reacción #2439968

Ecuación de reacción

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid

thionyl chloride

6-(4-Amino-benzoyl)-1,3-dihydro-indol-2-one

→

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide

Rendimiento 49.0%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe thionyl chloride then was removed by concentration in vacuo
2. 2
   TemperaturaThe crude acid chloride was cooled to room temperature
3. 3
   workup.DISSOLUTIONdissolved in THF (5 mL)
4. 4
   Temperaturato reflux for 4 h
5. 5
   Temperaturato cool to room temperature
6. 6
   OtroThe room temperature reaction mixture
7. 7
   Concentraciónwas concentrated in vacuo
8. 8
   workup.DISSOLUTIONthe crude residue was dissolved in EtOH (5 mL)
9. 9
   workup.ADDITIONThe ethanolic solution was treated with 1M NaOH(aq) (2 mL)
10. 10
    workup.STIRRINGstirred for 30 min
11. 11
    Otroyielding a precipitate
12. 12
    FiltraciónThe solids were filtered

Procedimiento

A dry 25 mL flask was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (0.887 g, 5.16 mmol) and thionyl chloride (5 mL) and allowed to stir at 79° C. for 2 h. The thionyl chloride then was removed by concentration in vacuo. The crude acid chloride was cooled to room temperature, and then dissolved in THF (5 mL). 6-(4-Amino-benzoyl)-1,3-dihydro-indol-2-one (1.00 g, 3.97 mmol) was added to the THF solution of the acid chloride, and the mixture was allowed to reflux for 4 h. The reaction mixture was then allowed to cool to room temperature. The room temperature reaction mixture was concentrated in vacuo, and the crude residue was dissolved in EtOH (5 mL). The ethanolic solution was treated with 1M NaOH(aq) (2 mL) and stirred for 30 min. The basic solution was acidified to a pH of 1 with 1M HCl(aq) yielding a precipitate. The solids were filtered to afford the pure 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (0.741 g, 1.94 mmol, 49%).

Fuente