Reacción #2439953

Ecuación de reacción

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide

THF

5-amino-2-methoxyphenol

→

title compound

Rendimiento 62.0%

2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid (4-{3-[(3-hydroxy-4-methyl-phenylamino)-methylene]-2-oxo-2,3-dihydro-1H-indole-5-carbonyl}-phenyl)-amide

Rendimiento 62.0%

Disolventes

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA small screw cap test tube
2. 2
   TemperaturaSubsequently, the reaction mixture was cooled to room temperature
3. 3
   OtroThe solid precipitate that formed

Procedimiento

A small screw cap test tube was charged with 2-Ethyl-5-methyl-2H-pyrazole-3-carboxylic acid [4-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-5-carbonyl)-phenyl]-amide (as prepared in Example 7, 70 mg, 0.168 mmol) and THF (2 mL). To the resulting solution was added 5-amino-2-methoxyphenol (22.8 mg, 0.184 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature. Hexanes were added to the reaction mixture. The solid precipitate that formed was washed with ˜1 mL of i-prOH yielding 62% (56 mg, 0.104 mmol) of the title compound.

Fuente