Reacción #2407

Ecuación de reacción

4,6-dichloropyrimidine

ethylene glycol

sodium hydride

→

2-(6-chloropyrimidin-4-yloxy)ethanol

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling
2. 2
   Otroevaporated
3. 3
   Otroto remove the solvent
4. 4
   ExtracciónThe residue is extracted with ethyl acetate
5. 5
   Extracciónthe ethyl acetate extract
6. 6
   Otrois dried
7. 7
   Concentraciónconcentrated under reduced pressure
8. 8
   OtroThe residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1)

Procedimiento

To a mixture of 4,6-dichloropyrimidine (5.0 g), ethylene glycol (100 ml) and tetrahydrofuran (100 ml)is added sodium hydride (60% dispersion-type, 1.34 g) under ice-cooling. The mixture is stirred at the same temperature for two hours, and evaporated to remove the solvent. The residue is extracted with ethyl acetate, and the ethyl acetate extract is dried, and concentrated under reduced pressure. The residue is purified by silica gel column chromatography (solvent; chloroform/ethyl acetate=5:1~2:1) to give 2-(6-chloropyrimidin-4-yloxy)ethanol (5.67 g) as an oily product.

Fuente