Reacción #2404

Ecuación de reacción

4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide

sodium hydride

ethylene glycol

hydrochloric acid

→

4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe ethyl acetate layer is washed
4. 4
   Otrodried
5. 5
   Otroevaporated
6. 6
   Otroto remove the solvent
7. 7
   OtroThe residue is crystallized from ethyl acetate

Procedimiento

To ethylene glycol (20 ml) is added sodium hydride (60% dispersion-type, 1.03 g), and thereto is added 4-tert-butyl-N-(6-chloropyrimidin-4-yl)benzenesulfonamide (1.66 g). The mixture is stirred at 60° C. for 20 hours. After cooling, the mixture is acidified with 10% hydrochloric acid, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from ethyl acetate to give 4-tert-butyl-N-{6-(2-hydroxyethoxy)pyrimidin-4-yl}benzenesulfonamide (1.58 g).

Fuente