Reacción #2401

Ecuación de reacción

ammonium chloride

6-chloro-5-(4-methylphenyl)pyrimidin-4-amine

sodium hydride

ethylene glycol

→

2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrois reacted at 70° C. for two hours
2. 2
   Otroreacted at 90° C. for five hours
3. 3
   Extracciónextracted with ethyl acetate
4. 4
   LavadoThe ethyl acetate layer is washed
5. 5
   Otrodried
6. 6
   Otroevaporated
7. 7
   Otroto remove the solvent
8. 8
   OtroThe residue is crystallized from hexane/ethyl acetate

Procedimiento

A mixture of 6-chloro-5-(4-methylphenyl)pyrimidin-4-amine (500 mg), ethylene glycol (10 ml) and sodium hydride (60% dispersion-type, 0.46 g) is reacted at 70° C. for two hours, and reacted at 90° C. for five hours. The mixture is treated with saturated aqueous ammonium chloride solution, and extracted with ethyl acetate. The ethyl acetate layer is washed, dried, and evaporated to remove the solvent. The residue is crystallized from hexane/ethyl acetate to give 2-{6-amino-5-(4-methylphenyl)pyrimidin-4-yloxy}-ethanol (422 mg).

Fuente