Reacción #2396544

Ecuación de reacción

sodium borohydride

chloroform

chloroform

ethanol

2-(4-(4-fluorophenacyl)-piperazinyl)-6-methyl-4-phenyl-thieno[2,3-d]pyrimidine

→

desired crystal

Rendimiento 94.4%

2-(4-(2-(4-FLUOROPHENYL)-2-HYDROXYETHYL)-PIPERAZINYL)-6-METHYL-4-PHENYL-THIENO[2,3-d]PYRIMIDINE

Rendimiento 94.4%

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter reaction for one hour
2. 2
   Otrotwo layers are separated
3. 3
   LavadoThe chloroform layer is washed with 100 ml of water
4. 4
   Secadowith saturated aqueous solution of sodium chloride, and dried over anhydrous sodum sulfate
5. 5
   workup.DISTILLATIONChloroform is distilled off

Procedimiento

Into a mixture of 10 ml of chloroform and 10 ml of ethanol is dissolved 1.34 g of 2-(4-(4-fluorophenacyl)-piperazinyl)-6-methyl-4-phenyl-thieno[2,3-d]pyrimidine, and then 0.23 g of sodium borohydride is added at room temperature. After reaction for one hour, 60 ml of chloroform and 100 ml of water are added and two layers are separated. The chloroform layer is washed with 100 ml of water and then with saturated aqueous solution of sodium chloride, and dried over anhydrous sodum sulfate. Chloroform is distilled off and 1.27 g of the desired crystal is obtained from methanol. The product has a melting point of 180°-181.5° C.

Fuente