Reacción #2396543

Ecuación de reacción

chloroform

6-methyl-4-phenyl-2-piperazinyl-thieno[2,3-d]pyrimidine

4-fluorophenacyl chloride

triethylamine

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product

Rendimiento 91.8%

2-(4-(4-FLUOROPHENACYL)-PIPERAZINYL)-6-METHYL-4-PHENYL-THIENO[2,3-d]PYRIMIDINE

Rendimiento 91.8%

Disolventes

methylethylketone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 5 hours
2. 2
   TemperaturaAfter cooling
3. 3
   LavadoThe solution is washed twice with 100 ml of water
4. 4
   Secadosaturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONAfter distilling off
6. 6
   Otrochloroform, crystallization from diethylether/methanol

Procedimiento

In 6 ml of methylethylketone, 2.03 g of 6-methyl-4-phenyl-2-piperazinyl-thieno[2,3-d]pyrimidine, 1.25 g of 4-fluorophenacyl chloride and 0.73 g of triethylamine are reacted under reflux for 5 hours. After cooling, 70 ml of chloroform is added to the reaction mixture. The solution is washed twice with 100 ml of water and then saturated aqueous solution of sodium chloride, and dried over anhydrous sodium sulfate. After distilling off chloroform, crystallization from diethylether/methanol gives 2.68 g of the product which has a melting point of 141°-142° C.

Fuente