Reacción #2390976

Ecuación de reacción

t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate

hydrogen chloride dioxane

→

title compound

5-{4-[6-(3-t-Butyl-4-hydroxyphenoxy)-1-methyl-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidin-2,4-dione hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent of the reaction mixture was evaporated to dryness and to the residue
2. 2
   workup.ADDITIONwas added ethyl acetate
3. 3
   Otroinsoluble product was isolated by filtration
4. 4
   Lavadowashed with ethyl acetate

Procedimiento

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxyacetylamino]-5-(3-t-butyl-4-hydroxyphenoxy)phenyl}-N-methylcarbamate (1.75 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at room temperature for 14 hours. The solvent of the reaction mixture was evaporated to dryness and to the residue was added ethyl acetate and insoluble product was isolated by filtration and washed with ethyl acetate to give the title compound (1.11 g).

Fuente