Reacción #2390970

Ecuación de reacción

t-butyl N-{2-[4-(2,4-dioxothiazolidine-5-ylmethyl)phenoxyacetylamino]-5-(4-phenoxyphenoxy)phenyl}-N-methylcarbamate

hydrogen chloride dioxane

→

title compound

5-{4-[1-Methyl-6-(4-phenoxyphenoxy)-1H-benzimidazole-2-ylmethoxy]benzyl}thiazolidine-2,4-dione hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent of the reaction mixture was evaporated to dryness
2. 2
   workup.ADDITIONTo the residue was added ethyl acetate and insoluble product
3. 3
   Filtraciónwas collected by filtration
4. 4
   Lavadowashed with ethyl acetate

Procedimiento

A mixture of t-butyl N-{2-[4-(2,4-dioxothiazolidine-5-ylmethyl)phenoxyacetylamino]-5-(4-phenoxyphenoxy)phenyl}-N-methylcarbamate (1.99 g) and 4N hydrogen chloride/dioxane (20 ml) was stirred at ambient temperature for 22 hours. The solvent of the reaction mixture was evaporated to dryness. To the residue was added ethyl acetate and insoluble product was collected by filtration and washed with ethyl acetate to give the title compound (1.57 g).

Fuente