Reacción #2380638

ord-35c894c60b4842a78375af59806588d1

Ecuación de reacción

CC(C)C[C@H](N)CN1CCC[C@H]1C(=O)NCCCCc1ccccc1
1-[2-(S)-amino-4-methylpentyl ]-L-proline 4-phenylbutylamide
O=C(Cl)c1cccc2c1-c1ccccc1C2=O
9-fluorenone-4-carbonyl chloride
→
CC(C)C[C@@H](CN1CCC[C@H]1C(=O)NCCCCc1ccccc1)NC(=O)c1cccc2c1-c1ccccc1C2=O
title compound
Rendimiento 18.0%
CC(C)C[C@@H](CN1CCC[C@H]1C(=O)NCCCCc1ccccc1)NC(=O)c1cccc2c1-c1ccccc1C2=O
1-[2-(S)-[(9-Oxo-9H-fluorene-4-carbonyl)amino]-4-methylpentyl]-L-proline 4-Phenylbutylamide
Rendimiento 18.0%

Reactantes

CC(C)C[C@H](N)CN1CCC[C@H]1C(=O)NCCCCc1ccccc1
1-[2-(S)-amino-4-methylpentyl ]-L-proline 4-phenylbutylamide
O=C(Cl)c1cccc2c1-c1ccccc1C2=O
9-fluorenone-4-carbonyl chloride

Reactivos

Ninguno

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Using the procedure described in Example 7, treatment of 1-[2-(S)-amino-4-methylpentyl ]-L-proline 4-phenylbutylamide (134 mg) with 9-fluorenone-4-carbonyl chloride (131 mg) provided 35 mg(18%) of the title compound. The 1H NMR and Mass spectrum analysis of this compound was consistent with the structure.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05686469uspto-grants-1997_11