Reacción #2374477

Ecuación de reacción

phenothiazine

p-iodotoluene

potassium carbonate

→

10-p-tolylphenothiazine

Rendimiento 75.4%

10-p-Tolylphenothiazine

Rendimiento 75.4%

Disolventes

diisopropylbenzene

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrowas reacted at 180° C. for 3 hours
2. 2
   TemperaturaThe mixture was then cooled
3. 3
   Filtraciónfiltered through a Celite
4. 4
   ConcentraciónThe filtrate was concentrated
5. 5
   Otrothe residual crystals were recrystallized from an ethanol/ethyl acetate mixed solvent

Procedimiento

A mixture of 25 g (0.126 mol) of phenothiazine, 33 g (0.151 mol) of p-iodotoluene, 4 g (0.025 mol) of copper sulfate, 23 g of potassium carbonate, and 200 ml of diisopropylbenzene was reacted at 180° C. for 3 hours and then at 200° C. for 1 day. The mixture was then cooled and filtered through a Celite. The filtrate was concentrated, and the residual crystals were recrystallized from an ethanol/ethyl acetate mixed solvent to obtain 27.5 g of 10-p-tolylphenothiazine (4b).

Fuente