Reacción #2374468

Ecuación de reacción

oxalyl chloride

2-fluoro-α-methyl-biphenylacetic acid

→

2-Fluoro-α-methyl-biphenylacetic acid chloride

Disolventes

methylene chloride

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added dropwise over a 30 minute period
2. 2
   Temperaturato warm to room temperature
3. 3
   OtroThe solvent was evaporated
4. 4
   Otroto give the product in a quantitative yield as a yellow solid

Procedimiento

Under a nitrogen atmosphere, oxalyl chloride (3.8 g, 30 mmol) was combined with methylene chloride (30 mL). The resulting mixture was cooled to 0° C. and dimethylformamide (10 drops) was added. After 5 minutes of stirring a solution of 2-fluoro-α-methyl-biphenylacetic acid (3.0 g, 12 mmol) in methylene chloride (30 mL) was added dropwise over a 30 minute period. The reaction mixture was allowed to warm to room temperature and stirred overnight. The solvent was evaporated to give the product in a quantitative yield as a yellow solid. 1H NMR (CDCl3) δ: 1.58 (d, 3 H), 4.20 (q, 1H), 7.11 (t, 2H), 7.33-7.47 (m, 4H), 7.54 (d, 2H).

Fuente